Dr. Lowella Esperanza was born in Staten Island, New York, and grew up in a Coast Guard family, which meant frequent moves before ultimately settling in St. Petersburg, Florida. She earned her medical degree at the University of South Florida College of Medicine in Tampa and completed her medical internship at the University of Alabama at Birmingham. Returning to Tampa, she completed her dermatology residency at the University of South Florida.

In 1996, Dr. Esperanza founded the Dermatology Department at the Florida Medical Clinic, a large multi-specialty group serving the Tampa Bay area. She is passionate about general dermatology, with a special focus on aesthetics and surgical dermatology. In addition to her busy practice, she enjoys teaching medical students and has been involved in outreach and educational programs in the community.

Dr. Esperanza resides in Tampa with her husband, Dr. Emilio Dominguez, a retired infectious disease physician, and enjoys spending time with her family, gardening, hiking and traveling.